QB Graduate Program Faculty Members

IQB Members come from virtually all of Rutgers STEM-related schools and centers, including the Schools of Arts and Sciences (SAS), Engineering (SOE), Environmental and Biological Sciences (SEBS), Health Professions (SHP), the Ernest Mario School of Pharmacy (EMSOP), the Graduate School-Newark (GS-N), the New Jersey Medical School (NJMS), the Robert Wood Johnson Medical School (RWJMS), the Cancer Institute of New Jersey (CINJ), the Center for Advanced Biotechnology and Medicine (CABM), the Child Health Institute of New Jersey (CHINJ), the Environmental and Occupational and Health Sciences Institute (EOHSI), the Human Genetics Institute of New Jersey (HGINJ/RUCDR Infinite Biologics), the New Jersey Institute for Food, Nutrition, and Health (NJIFNH), the Waksman Institute of Microbiology (WIM), and the Office of Research and Economic Development (ORED).

Gabriela Alexe
Adjunct Faculty
Broad Institute

One research direction is Integrative Cancer Genomics, where I am working on extracting and creating knowledge from multiple genomic data platforms to explore the global mechanisms of cancer initiation, progression and metastasis, with a particular emphasis on discovering driver genetic events and combinatorial biomarkers for improving risk profiling, therapy specificity and treatment efficacy. The second research direction is Cancer Immunology, where I am working on deciphering the mechanisms associated with T cell dysfunction and immune signatures in cancer.
Dana-Farber Cancer Institute
Room 610
616-632-6782

David Alland
Professor
Medicine, Rutgers New Jersey Medical School
Chief, Infectious Diseases
Resident Member, Public Health Research Institute
Associate Dean, Clinical Research

The Alland laboratory is interested in many different aspects of M. tuberculosis molecular biology, epidemiology and diagnostics. Many of these areas are related to understanding how antibiotic resistance develops on both the cellular and epidemiological level. We also have a major program in biodefense diagnostics and pathogenesis.
Medical Sciences Building
Room A920C
973-972-9834

Ioannis Androulakis
Professor and Undergraduate Program Director
Biomedical Engineering, School of Engineering

Our research interests focus on the quantitative systems biology and quantitative systems pharmacology of inflammation and the interplay between immune response and biological rhythms. We are interested in delineating the intricacies of the human response to stress as well as characterizing responses to drugs, including the opportunities for personalizing oral drug formulations to target groups according to sex, age and disease status.
Biomedical Engineering
Room 212
848-445-6561

Gail Ferstandig Arnold
Associate Director, Graduate Studies and Academic Affairs
Institute for Quantitative Biomedicine
Research Professor, Chemistry & Chemical Biology, School of Arts & Sciences

After more than 20 years leading an AIDS vaccine research group at Rutgers, I am now dedicated to: (1) working with Founding Director, Stephen Burley, to develop the Institute for Quantitative Biomedicine into a truly interactive community of basic and applied scientists, clinicians and colleagues in industry working in collaboration to address important biological and biomedical challenges and (2) working with the Graduate Program Director to develop the Quantitative Biomedicine graduate program and its partnering Joint Ph.D. program into a modern interdisciplinary program that will complement the many strengths already at Rutgers and promote broadly collaborative scientific investigation in a way that parallels the visions of the Institute.
Institute for Quantitative Biomedicine
Room 105
848-445-8377

Eddy Arnold
Board of Governors Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Resident Member, Center for Advanced Biotechnology & Medicine
Full Member, Rutgers Cancer Institute of New Jersey

Drug design and development targeting HIV/AIDS and flu, and structural biology of HIV-1 reverse transcriptase and integrase, flu polymerase, and bacterial RNA polymerases. A key focal area is to define the structural basis of drug resistance in infectious diseases, and to use structural information to design drugs to overcome drug resistance, including the development of generally applicable strategies.
Center for Advanced Biotechnology & Medicine
Room 016
848-445-9777

Gary Aston-Jones
Director, Brain Health Institute
Murray and Charlotte Strongwater Endowed Chair in Neuroscience & Brain Health
Rutgers Biomedical & Health Sciences

Brain neuromodulatory systems, cognitive performance, drug abuse, sleep and waking, and affective disorders
Rutgers Brain Health Institute
Room 259A
732-235-6077

David E. Axelrod
Professor
Genetics, School of Arts & Sciences

Our lab is interested in developing quantitative prognostic factors for detecting early stages of breast and colon cancer, stratifying patients for good and poor survival, and suggesting improved treatments of patients with cancer. We combine experimental techniques such as image analysis of human biopsy specimens to measure the expression of oncogenes and tumor suppressor genes and proteins; and mathematical and computer modeling to develop agent based models of normal stem cell stochastic dynamics, abnormal proliferation and development, initiation of cancer, progression to invasive cancer, tumor heterogeneity, and chemoprevention.
Nelson Biology Laboratories
Room B341
848-445-2011

Jean Baum
Distinguished Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

Our research focuses on the mechanism behind protein recognition and proteins aggregation. Methods of high-resolution nuclear magnetic resonance (NMR) spectroscopy in conjunction with other biophysical methods, computer algorithms and molecular biology are used to examine the dynamics and three-dimensional structures of proteins in solution.
Center for Integrative Proteomics Research
Room 308NP
848-445-5254

William Belden
Associate Professor
Animal Sciences, School of Environmental & Biological Sciences

The research in my laboratory focuses on understanding the molecular aspects of chromatin-remodeling and circadian rhythms. My lab uses the highly-tractable model eukaryote Neurospora crassa in combination with biochemical, genetic and genome-wide studies to understand the molecular mechanisms of chromatin-remodeling in clock function.
Foran Hall
Room 326
848-932-5617

Helen M. Berman
Board of Governors Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Director Emerita, RCSB Protein Data Bank
Founding Director, Center for Integrative Proteomics Research
Resident Member, Institute for Quantitative Biomedicine

As head of the Research Collaboratory for Structural Bioinformatics (RCSB), Director of the Protein Data Bank (PDB), and founding member of the Worldwide Protein Data Bank (wwPDB) collaboration, my group supports scientific research and education worldwide by providing the essential PDB archive of information about the experimentally-determined structures of proteins, nucleic acids, and complex assemblies. Other biological data management projects include EMDataBank, a global deposition and retrieval network for 3DEM map, model, and associated metadata, and the Structural Biology Knowledgebase, an online resource that combines the products of the NIH-funded Protein Structure Initiative research with external data annotations to provide comprehensive information about proteins.
Center for Integrative Proteomics Research
Room 208NP
848-445-4667

Debashish Bhattacharya
Distinguished Professor
Ecology, Evolution & Natural Resources, School of Environmental & Biological Sciences

Work in the Bhattacharya lab primarily addresses the origin and evolution of photosynthetic eukaryotes. We use a variety of techniques ranging from algal culture and physiology, standard and single cell genomics, and functional genomics to study how algae gained and orchestrate the functions of their photosynthetic organelle, the plastid and how they adapt to changing environmental conditions. We have recently initiated a large-scale genomic and functional genomic analysis of corals and their symbionts to understand the basis of biomineralization, the genetic structure of coral populations, and their pathways of stress tolerance.
Foran Hall
Room 102
848-932-6218

Kenneth J. Breslauer
Linus C. Pauling Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Dean, Biological Sciences
Vice President, Health Science Partnerships

The research conducted in my laboratory combines both biophysical and bioorganic chemistry to investigate the following four interrelated programs of research.
Wright Rieman Laboratories
Room 155
732-445-3954

Yana Bromberg
Associate Professor
Biochemistry & Microbiology, School of Environmental & Biological Sciences

Bioinformatics approaches to protein function prediction and genome variation analysis. Our main goal is to develop fast, accurate, and meaningful ways of analyzing this growing deluge of biological data and to bring these developments bench- (or patient-) side. To make our predictions we rely on a number of sequence-based features (including evolutionary information and other predictor results) and utilize a variety of methodologies (including Neural Nets, SVMs and random forests).
Lipman Hall
Room 218
848-932-5638

Linda Brzustowicz
Distinguished Professor & Chair
Genetics, School of Arts & Sciences
Full Academic Member, Human Genetics Institute of New Jersey

My research group applies the techniques of molecular and statistical genetics to approach clinically relevant problems in neuroscience, with the ultimate goal of understanding gene function in both the pathologic and normal states. We are currently studying schizophrenia, autism, and specific language impairment (SLI). Work directly conducted by my group includes development of phenotype definitions, subject recruitment and assessment (for autism and SLI), genotyping and statistical analysis for linkage and association studies, comparative genomic analysis, and gene expression studies.
Life Sciences
Room 231
848-445-1638

Stephen K. Burley
University Professor & Henry Rutgers Chair
Founding Director, Institute for Quantitative Biomedicine
Director, Center for Integrative Proteomics Research
Director, RCSB Protein Data Bank
Member, Rutgers Cancer Institute of New Jersey

As the Director of the Center for Integrative Proteomics Research, a Professor in the Department of Chemistry and Chemical Biology at Rutgers, The State University of New Jersey, and a Member of The Cancer Institute of New Jersey, I aim to foster interactive networks of research groups that utilize multidisciplinary approaches to address important biological and biomedical challenges.
Center for Integrative Proteomics Research
Room 117

David Case
Distinguished Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

Our group studies theoretical chemistry of biomolecules, using molecular dynamics simulations of proteins and nucleic acids, electronic structure calculations of transition-metal complexes that model active sites in metalloenzymes, and development and application of methods for NMR structure determination.
Center for Integrative Proteomics Research
Room 208AB
848-445-5885

Chang S. Chan
Assistant Professor
Medicine, Robert Wood Johnson Medical School
Resident Member, Rutgers Cancer Institute of New Jersey
Associate Director, Center for Systems & Computational Biology

High-throughput sequencing and integration of data in the study of genetics of cancer, complex diseases, and gene regulation, and Integration of diverse data with phenotypes for a systems level understanding of biology
Rutgers Cancer Institute of New Jersey
732-235-7363

Sunita Chaudhary
Adjunct Assistant Professor
Surgery, Robert Wood Johnson Medical School
Director, Research Education
Resident Member, Rutgers Cancer Institute of New Jersey

Our current research focuses on understanding the influence of race, gender and immigration status on biomedical career choice.
Rutgers Cancer Institute of New Jersey
Room 8005
732-235-9869

Neeraj Chauhan
Assistant Professor
Microbiology & Molecular Genetics, Rutgers New Jersey Medical School
Resident Member, Public Health Research Institute

The focus of my current research is the opportunistic human pathogenic yeast, Candida albicans. It is the leading cause of invasive fungal disease in premature infants, surgical patients and cancer patients receiving immunosuppressive chemotherapy. My research is directed to elucidate the complex signaling pathways that contribute to the virulence & pathogenesis of this organism. Our approaches include molecular, biochemical and immunological techniques to study these events. This involves isolation of encoding genes, construction of knock-out strains to study gene function, DNA Microarrays, and GFP localization etc. Two component signaling proteins (histidine kinases and response regulators) and downstream MAP kinases are the main focus of research.
Public Health Research Institute
973-854-3470

Shishir Chundawat
Assistant Professor
Chemical & Biochemical Engineering, School of Engineering

Our group takes a 'glycan-centric' approach to address a variety of problems in bioenergy, biomedical, and biomaterials engineering.
School of Engineering
Room C-150A
848-445-3678

Davide Comoletti
Assistant Professor
Neuroscience & Cell Biology, Robert Wood Johnson Medical School
Resident Member, Child Health Institute of New Jersey

In our lab we study the structural and molecular basis of synapse formation and connectivity in relation to ASD. We focus on the three-dimensional structure and cellular functions of several trans-synaptic adhesion molecules such as the neuroligins, neurexins, LRRTMs (see selected publication below). Besides these well-known proteins, other novel associating proteins have been recently discovered by us and by others and are currently under investigation in the lab. We use structural biology and cellular neuroscience to gain insights into how mutations of these proteins associate with autism and other common neurodevelopmental disorders.
Child Health Institute of New Jersey
Room 4274
732-235-9466

William Craelius
Professor
Biomedical Engineering, School of Engineering

In my lab, we study how technology can restore mobility to persons with missing or impaired limbs. My research with amputees developed the first prosthesis that restored multiple finger dexterity. Since then I have translated this technology to assist those with paralysis due to brain injuries. My work with many clients having arm paralysis due to stroke, brain injury and cerebral palsy, has taught me both the potential and limitations of tools that attempt to promote neuroplastic recovery in these populations. I employ technology to measure arm motion and hand control, using cameras and various sensors, and have demonstrated their therapeutic potential. We are also developing new growth substrates for helping nerves regenerate.
Biomedical Engineering
Room 207
848-445-6558

Wei Dai
Assistant Professor
Cell Biology & Neuroscience, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine
Associate Member, Rutgers Cancer Institute of New Jersey

Our research focuses on charactering the structures of macromolecular machinery in their cellular context using three-dimensional (3D) cryo-electron tomography (cryoET) and correlative light and electron microscopy. Structures of intracellular macromolecular complexes are usually heterogeneous and dynamic, relying largely on interactions with other cellular components. Using cryoET to determine the structure of cellular machinery inside the cell avoids damage to the complexes during purification, captures snapshots of the complex while in action, and provides information on cross-talk of the complexes with their cellular partners during biological processes. Our current research interest includes: Huntington's disease: structure and organization of protein aggregates; 3D architecture of the diseased cells under misfolded protein aggregation stress & Structural biology of phage/virus maturation.
Center for Integrative Proteomics Research
Room 208G
848-445-6560

Subhajyoti De
Assistant Professor
Pathology & Laboratory Medicine, Robert Wood Johnson Medical School
Systems & Computational Biology
Resident Member, Rutgers Cancer Institute of New Jersey

The De laboratory develops and applies genomics, systems biology, and mathematical modeling approaches to understand the biology of cancer and use that knowledge for better diagnosis, stratification of cancer patients and their personalized treatment.
Rutgers Cancer Institute of New Jersey
732-235-8558

Justin Drake
Assistant Professor
Resident Member, Rutgers Cancer Institute of New Jersey
Medicine, Robert Wood Johnson Medical School

Research in the Drake Lab focuses on blending basic and translational research approaches to better understand the signaling networks in lethal metastatic castration resistant prostate cancer, and how to more effectively treat patients who are suffering from this disease using rationalized targeted therapies.
Rutgers Cancer Institute of New Jersey
Room 4507
732-235-7017

Monica Driscoll
Distinguished Professor
Molecular Biology & Biochemistry, School of Arts & Sciences

Our lab uses the elegant and powerful model system C. elegans to decipher conserved molecular mechanisms of cellular function and dysfunction. The main problems we investigate are neuronal degeneration, neuronal regeneration, and the biology of aging, with a focused goal of defining strategies for extending healthspan.
Nelson Biology Laboratories
Room A232
848-445-7182

Siobain Duffy
Associate Professor
Ecology, Evolution & Natural Resources, School of Environmental & Biological Sciences

The Duffy lab uses a blend of computational and experimental approaches to understand and model the evolution of emerging RNA and single-stranded DNA viruses.
Foran Hall
Room 316
848-932-6299

Shuchismita Dutta
Scientific Educational Development Lead
RCSB Protein Data Bank

I am a structural biologist, dedicated to promoting a molecular structural view of biology and medicine. I am also committed to STEM Education, and interested in Science Pedagogy.
Center for Integrative Proteomics Research
Room 114
848-445-4915

Richard H. Ebright
Board of Governors Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Principal Investigator, Waksman Institute of Microbiology

Richard H. Ebright seeks to understand structures, mechanisms, and regulation of bacterial transcription complexes and to identify, characterize, and develop small-molecule inhibitors of bacterial transcription for application as antituberculosis agents and broad-spectrum antibacterial agents.
Waksman Institute of Microbiology
Room 201-A
848-445-5179

Laura Fabris
Associate Professor
Materials Science & Engineering, School of Engineering

We are interested in the synthesis and characterization of plasmonic nanoparticles and their use in surface enhanced Raman scattering (SERS)-based sensing and cell imaging, and in those applications that require near field enhancement effects. We also focus on the study of nanoparticle assembly in solution and on unraveling the fundamental phenomena at the basis of ligand exchange in plasmonic nanoparticles in solution.
McLaren Center for Ceramic Research
Room 216
848-445-5606

Paul Falkowski
Board of Governors Professor & Bennett L. Smith Chair, Business & Natural Resources
Earth & Planetary Sciences and Marine & Coastal Sciences, School of Environmental & Biological Sciences
Director, Rutgers Energy Institute

My research interests are focused on three areas - origins of life, how electron transfer reactions are mediated, and how organisms transformed the geochemistry of Earth. In the evolution of Earth, microbes became a major force in transforming this planet to make it habitable for animals, including humans. I seek to understand the basic chemical reactions that enabled microbes to transform Earth's goechemistry. I work at the molecular level of proteins and fundamental chemical reactions of minerals, and the global scale of how this planet came to have oxygen as the second most abundant gas. I am most interested in understanding how these kinds of processes have transformed our planet and may evolve on planetary bodies in our solar system and on extra-solar planets. There are only two questions I address: Where did we come from? And are we alone?
Institute of Marine & Coastal Sciences
Room 318D
848-932-3426

Zukang Feng
Principal Scientific Application/Web Developer
RCSB Protein Data Bank

My research interest focuses on developing tools for data acquisition, data validation, data standardization, and data analysis in the structural biology.
Center for Integrative Proteomics Research
Room 113

David J. Foran
Professor
Pathology and Laboratory Medicine; Radiology, Robert Wood Johnson Medical School
Director, Center for Biomedical Imaging
Resident Member, Rutgers Cancer Center of New Jersey

A major concentration for my laboratory has been the development of a family of data-mining, imaging and computational tools for characterizing a wide range of malignancies and elucidating the role that protein and molecular expression plays in disease onset and progression. My training, experience and expertise gained while leading and supporting multi-investigator projects in computational imaging, computer-assisted diagnostics, bioinformatics, team-based software development and high-performance computing have provided me with the requisite tools and skills to work in partnership with basic, clinical and translational researchers to address fundamental problems in cancer detection, patient stratification, disease management, and outcomes studies.
Rutgers Cancer Institute of New Jersey
Room 3552
732-235-6925

Joel Freundlich
Associate Professor
Pharmacology, Physiology & Neuroscience, Rutgers New Jersey Medical School

The Freundlich group is a chemical biology lab that utilizes a multi-disciplinary approach to study infectious diseases, with a specific focus on tuberculosis. Within the Department of Pharmacology & Physiology and the Department of Medicine (Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens), we focus on 1) the development and application of novel computational methods to discover and optimize chemical probes with which to study the pathogenesis of disease and 2) the utilization of biological techniques to elucidate how each probe affects disease pathogenesis, often through the complex modulation of more than one biological target. We assert that this approach has significant potential to seed the discovery of novel biological targets and small molecule drug discovery hits/leads.
Medical Sciences Building
Room I-503
973-972-7165

Zoran Gajic
Professor
Electrical & Computer Engineering, School of Engineering
Graduate Program Director

Research interests are in controls systems, energy systems (fuel and solar cells, wind, smart grids), wireless communications, and networking.
Electrical Engineering
Room 134A
732-445-3415

Shridar Ganesan
Associate Professor & Omar Boraie Chair, Genomic Science
Medicine & Pharmacology, Robert Wood Johnson Medical School
Resident Member, Rutgers Cancer Institute of New Jersey
Section Chief, Molecular Oncology
Associate Director, Translational Science

With a research interest in breast cancer biology and DNA repair, I am currently exploring how DNA repair defects in cancers can be exploited to develop novel effective treatments. I am also active in applying next-generation sequencing technology to identify specific genomic changes in cancers that can be therapeutically targeted. As a physician/scientist I both run a basic research laboratory focused on breast cancer biology and see patients in the Stacy Goldstein Breast Cancer Center. In the clinic, I work collaboratively with experts across multi-disciplines and have the opportunity to put theory into practice as we aim to develop the next generation of targeted treatments for breast cancer. Working with a team of radiation oncologists, surgical oncologists, nurses, social workers, genetic specialists and others, I help patients understand their specific disease and their treatment options so that they can make informed decisions. I am also an associate professor of medicine and pharmacology at Robert Wood Johnson Medical School.
Rutgers Cancer Institute of New Jersey
732-235-7428

Marc R. Gartenberg
Professor
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School
Full Member, Rutgers Cancer Institute of New Jersey

My lab investigates the ways that heterochromatin is assembled, maintained and inherited. Our recent work includes focus on the specialized roles of heterochromatin in sister chromatid cohesion. We use budding yeast as a model eukaryotic system where we have developed molecular biological tools to ask questions at the mechanistic level.
Robert Wood Johnson Medical School Research Building/School of Public Health
Room 284
732-235-5800

Michael Gatza
Assistant Professor
Radiation Oncology, Robert Wood Johnson Medical School
Resident Member, Rutgers Cancer Institute of New Jersey

Our research program is focused on understanding the mechanisms of oncogenic signaling and therapeutic response in human breast and ovarian cancers. Leveraging a multi-disciplinary approach spanning cancer biology, molecular biology, genomics, genetics, bioinformatics, and statistics allows us to identify relevant genomic alterations in human tumors and then experimentally investigate the mechanisms by which these alterations affect given tumor phenotypes in order to develop rational therapeutic strategies based on the unique complement of genomic alterations present in each patient's tumor.
Rutgers Cancer Institute of New Jersey
Room 4558
732-235-8751

Panos Georgopoulos
Professor
Rutgers Biomedical & Health Sciences
Director, Ozone Research Center

Multiscale computational modeling of environmental and biological systems and of their interactions; computational toxicology; quantitative frameworks for adverse outcome pathways in environmental health systems.
Enviroinformatics, bioinformatics, and socioinformatics for public health applications; predictive data analytics for human exposures and associated health outcomes.
Environmental & Occupational Health Sciences Institute
Room 308
848-445-0159

Nasrin Ghesani
Associate Professor
Radiology, Rutgers New Jersey Medical School

Molecular imaging and Positron Emission Tomography
University Hospital, Newark
Room UH 141
973-972-1770

David Goodsell
Associate Professor
Molecular Biology, The Scripps Research Institute
Research Professor, Chemistry & Chemical Biology, Rutgers University

My research uses computer graphics and simulation to explore structure/function relationships in key biological systems. For two decades, I have pioneered approaches for the integrative modeling of the cellular mesoscale, visualizing the molecular structure of cellular environments and entire cells. Building on AutoDock, the first method for computational docking of flexible molecules to proteins and DNA, I continue to develop advanced docking methods and apply them to the understanding of HIV and its interaction with cells of the immune system. Science education is also a strong focus of my laboratory. I am author of the Molecule of the Month, a feature at the RCSB Protein Data Bank that presents the structure and function of a new molecule each month, and several illustrated books on biological molecules, their diverse roles within living cells, and the growing connections between biology and nanotechnology.
The Scripps Research Institute
858-784-2839

Masayori Inouye
Distinguished Professor
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School

Molecular biology of cellular adaptation to stresses
Center for Advanced Biotechnology & Medicine
Room 140
848-445-9813

Kenneth Irvine
Distinguished Professor
Molecular Biology & Biochemistry, School of Arts & Sciences
Principal Investigator, Waksman Institute of Microbiology

The lab is engaged in projects whose long-term goal is to define relationships between patterning and growth in developing and regenerating organs. Much of their research takes advantage of the powerful genetic, molecular, and cellular techniques available in Drosophila melanogaster, which facilitate both gene discovery and the analysis of gene function.
Waksman Institute of Microbiology
Room 0136
848-445-3382

Mehdi Javanmard
Assistant Professor
Electrical & Computer Engineering, School of Engineering

Our lab focuses on exploiting emerging micro- and nanotechnologies for health and environmental monitoring.
Electrical & Computer Engineering Room 211
848-445-3382

Shantenu Jha
Associate Professor
Electrical & Computer Engineering, School of Engineering

High-performance and distributed computing; computational and data-intensive science and engineering
Electrical Engineering
Room 211

Jason Kaelber
Director, Rutgers New Jersey CryoEM/CryoET Core Facility
Institute for Quantitative Biomedicine
Assistant Research Professor, Chemistry & Chemical Biology, School of Arts & Sciences

As director of the cryoEM/ET core facility, I support structural biology research across the IQB and Rutgers community via scientific collaborations, technical services, and the development of new methods. Cryoelectron microscopy can solve structures of biomolecules in their native states at atomic resolution; it is fundamentally a single-molecule imaging technique, and by developing project-specific strategies, we can test hypotheses over a set of individual molecules. Additionally, I investigate the deep evolutionary history of viruses through comparative structural analyses. I have a specific interest in ssDNA viruses including their potential applications.
Institute for Quantitative Biomedicine
Room 010D
848-445-5302

Andrew Kern
Associate Professor
Genetics, School of Arts & Sciences

Our research focuses on variation among individuals in the genomes of humans, fruit flies, and plants. In particular we are interested in the role that natural selection has played in shaping patterns of genome variation. Look around you- casual observation of the natural world leads to the intuition that organisms are superbly adapted to their environments. We are interested in dissecting these adaptations at the genomic level, and in turn learning about the nature of the adaptive process. To this end we use computational and mathematical approaches towards using genome sequence data for evolutionary inference.
Nelson Biological Laboratories
848-445-3986

Sagar Khare
Assistant Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

The Khare lab seeks to develop new enzymes and proteins using a combination of computational protein design and experimental characterization. Our goal is to develop a quantitative and predictive understanding of enzymatic structures and functions and use this understanding to inform various therapeutic and synthetic applications. Some areas of interest are biodegradation of pollutants, improving cancer chemotherapy, and designing catalytic protein drugs.
Center for Integrative Proteomics Research
Room 208M
848-445-5143

Hossein Khiabanian
Assistant Professor
Pathology & Laboratory Medicine, Robert Wood Johnson Medical School

The research of our laboratory at Rutgers Cancer Institute of New Jersey focuses on cancer genomics and computational biology. We develop novel analytical methods to understand the underlying genetics of human diseases and the molecular epidemiology of disease-causing organisms using high-throughput genomic data. We are interested in identifying prognostic markers in cancer, as well as studying tumor clonal evolution, especially in the contexts of therapeutic resistance, disease transformation, and relapse.
Rutgers Cancer Institute of New Jersey
Room 3558
732-235-7445

David Kimball
Research Professor
Medicinal Chemistry, Ernest Mario School of Pharmacy
Vice President of Innovation and Research Commercialization, Office of Research & Economic Development
Associate Member, Rutgers Cancer Institute of New Jersey

The role of ApoE in Alzheimer disease, traumatic brain injury and the structure-based design of kinase inhibitors for cancer and inflammatory disease.
Rutgers Translational Sciences
848-932-4455

John Kolassa
Professor
Statistics & Biostatistics, School of Arts & Sciences

Explore approximate and exact statistical methods for small data sets.
Hill Center
Room 504
848-445-7674

Arek Kulczyk
Assistant Professor
Biochemistry & Microbiology, School of Environmental & Biological Sciences
Resident Member, Institute for Quantitative Biomedicine

Our laboratory integrates structural approaches, in particular single-particle cryo-electron microscopy (cryo-EM) and single-molecule techniques to study DNA replication and repair in human mitochondria. We also develop novel correlative light and electron microscopy (CLEM) methods that allow simultaneous visualization of an enzymatic activity and structure determination.
Institute for Quantitative Biomedicine
Room 208H
848-445-4553

Edmund Lattime
Professor
Surgery, Robert Wood Johnson Medical School
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School
Resident Member, Rutgers Cancer Institute of New Jersey

The primary focus of our laboratory is the study of the tumor host interaction with the ultimate gial being the design of effective immunotherapy regimens for cancer. The interaction between the host immune system and tumor is a multifaceted one with the generation of productive immunity requiring the cooperation of immune cells from multiple lineages. Further complicating the system. tumor cells themselves can produce immune suppressive factors.
Rutgers Cancer Institute of New Jersey
Room 2010
732-235-8588

Catherine Lawson
Associate Research Professor
Chemistry & Chemical Biology, School of Arts & Sciences

My research explores the diverse landscape of biological structure-function relationships, with the goal of improving our fundamental understanding of life processes. My current projects involve structure database development (EMDataBank, Protein Data Bank), with particular emphasis on improving representation of large biological assemblies.
Center for Integrative Proteomics Research
Room 109
848-445-5494

Joel Lebowitz
George William Hill Professor
Mathematics, School of Arts & Sciences
Director, Center for Mathematical Sciences Research

Mathematical physics and statistical mechanics
Hill Center
Room 612
848-445-3117

Jeehiun Katherine Lee
Professor
Chemistry & Chemical Biology, School of Arts & Sciences

Our group combines experimental and computational methods to understand mechanisms of reactions important for chemistry and biology. Specifically, we utilize traditionally physical methods, primarily mass spectrometry and computational chemistry, to tackle problems at the chemistry/biology interface, focusing on catalysis. We work on both biological catalysis, uncovering the mechanisms by which enzymes excise damaged DNA from the genome; as well as organic catalysis, examining N-heterocyclic carbenes as organocatalysts.
Wright Rieman Laboratories
Rooms 382 & 372
848-445-6562

Kibum Lee
Professor
Chemistry & Chemical Biology, School of Arts & Sciences

The primary research interest of my group is to develop and integrate nanotechnologies and chemical functional genomics to modulate signaling pathways in stem cells towards specific cell lineages or behaviors. In particular, we are exploring critical problems in cancer research and stem cell biology pertaining to the cell-microenvironmental interactions, and how to control these interactions at the subcellular and single cell level using chemical biology and nanotechnology. From this research effort, we have developed innovative technology platforms that may overcome the critical barriers to harnessing the full therapeutic potential of stem cells for regenerative medicine and personized medicine.
Wright Rieman Laboratories
Room 315
848-445-2081

Sang-Hyuk Lee
Assistant Professor
Physics & Astronomy, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

Lee lab is a single-molecule biophysics/biophotonics laboratory. Our lab features a wetlab, cell culture facility, and a one-of-a-kind single-molecule optical instrument. Utilizing advanced fluorescent microscopy, optical tweezers, and digital holography, we are pushing the limit of our understanding of biological processes at the single-molecule level.
Center for Integrative Proteomics Research
Room 308A
848-445-5286

Peter Lobel
Professor
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School
Resident Member, Center for Advanced Biotechnology & Medicine

Our laboratory studies lysosomes and associated human. Lysosomes are organelles found in all eukaryotic cells that contain many different proteases, glycosidases, lipases and other hydrolytic enzymes. The lysosome functions as the cell's recycling compartment, breaking down complex biological macromolecules into simple components. The importance of these organelles is underscored by the existence of over thirty human genetic disorders (e.g.. Tay-Sachs disease) where loss of function of a single lysosomal enzyme can lead to severe health problems including neurodegeneration, progressive mental retardation, and early death.
Center for Advanced Biotechnology & Medicine
Room 204
848-445-9831

Richard Ludescher
Professor
Food Science, School of Environmental & Biological Sciences
Dean, Academic Programs

The research in my lab is concerned with the physical chemistry of edible molecules and biomaterials, with the physical properties, molecular mobility, and molecular states of amorphous solids, and with developing novel applications of luminescence spectroscopy, and especially the identification, characterization and use of edible optical luminescent (fluorescent and phosphorescent) probes, to solve basic scientific as well as practical problems related to the structure, dynamics and function of edible biomaterials.
Martin Hall
Room 216
848-932-3516

David M. Lukac
Associate Professor
Microbiology, Biochemistry & Molecular Genetics, Rutgers New Jersey Medical School
Director, Graduate Track in Infection, Immunity & Inflammation

We have two major projects: 1. using herpesvirus infection models to investigate the specificity of cellular responses to the Notch signal transduction pathway, and application of learned paradigms to non-viral cancers. 2. investigating the intracellular dynamics of histone deacetylase 6 in autophagy, the stress response, and herpesviral infection.
International Center for Public Health
Room E-350 C
973-972-4868

Michael B. Mathews
Professor & Chair
Biochemistry & Molecular Biology, Rutgers New Jersey Medical School
Member, Rutgers Cancer Institute of New Jersey

His research interests include the control of gene expression, HIV and AIDS, and cellular antiviral defenses. Work in his lab is focused on regulatory systems involved in human disease and host defenses, with RNA-protein interactions as a common theme.
New Jersey Medical School-University Hospital Cancer Research Center
Room F1220
973-972-3133

Joachim Messing
University Professor & Selman A. Waksman Chair
Molecular Biology
Director, Waksman Institute of Microbiology

His laboratory has studied in particular genes that are expressed during the development of cereal seeds. He is well known for the genomic studies of grass genomes and his laboratory has contributed to the sequencing of rice, sorghum, maize, Brachypodium, and Spirodela. These genomic sequences have permitted his laboratory to study the organization and evolution of the genes that control the supply of proteins for nutrition. More recently, his laboratory has used RNA interference to study the role of these proteins in seed development and molecular breeding. One of the new initiatives of his laboratory investigates the potential of sweet sorghum and duckweed as alternative bio-energy sources.
Waksman Institute of Microbiology
848-445-4257

Dimitris Metaxas
Distinguished Professor
Computer Science, School of Arts & Sciences

Physics-based techniques for modeling of organ shape and motion; computer graphics and animation; computational vision; medical imaging
Computational Biomedicine Imaging & Modeling Center
Room 11
848-445-2914

James Millonig
Associate Professor
Neuroscience & Cell Biology, Robert Wood Johnson Medical School
Senior Associate Dean, School of Graduate Studies

My lab studies dorsal CNS development by taking the unique approach of combining mouse genetics with neuroanatomy. Our goal is to identify the pathways, which control the generation and differentiation of dorsal CNS neurons.
Center for Advanced Biotechnology & Medicine
Room 238
848-445-9852

Konstantin Mischaikow
Distinguished Professor
Mathematics, School of Arts & Sciences

We use algebraic and computational topological methods to investigate the global structures of multiparameter nonlinear dynamical systems and to study high dimensional spatially-temporally complex data sets.
Hill Center
Room 265
848-445-2395

Antonina Mitrofanova
Assistant Professor
Health Informatics, School of Health Professions
Director, Biomedical Informatics Research

Her laboratory investigates transcriptional as well as epigenetic mechanisms that drive cancer initiation, progression, and metastases. Furthermore, her lab interests expand to elucidating mechanisms of drug response and resistance and identifying novel drug and drug combinations to target cancer malignancies.
Health Informatics
Room 923B
973-972-5241

Prabhas Moghe
Distinguished Professor
Biomedical Engineering, School of Engineering

The Moghe laboratory has four broad research areas. Two of the areas focus on the design, synthesis, characterization, and mechanisms of interactions of nanoscale materials with cellular matrix proteins. A third area is focused on cell reporter-based biological profiling biological profiling of synthetic polymeric biomaterials for regenerative medicine using high content imaging and high throughput evaluation methods. The fourth effort is on studies of human embryonic stem cell pluripotency and differentiation behaviors on biomaterials.
Biomedical Engineering
Room 315
848-445-6591

Gaetano Montelione
Jerome and Lorraine Aresty Chair in Cancer Biology and Distinguished Professor
Molecular Biology & Biochemistry, School of Arts & Sciences
Member, Cancer Institute of New Jersey

We are interested in understanding basic principles of protein evolution and function. In a wide range of collaborations, we utilize structural bioinformatics and experimental methods, including NMR spectroscopy, X-ray crystallography, protein structure prediction, and small angle X-ray scattering (SAXS), to study proteins and protein complexes selected from interaction networks associated with cancer biology and the innate immune response.
Center for Advanced Biotechnology & Medicine
Room 307
848-445-9868

Alexandre Morozov
Associate Professor
Physics & Astronomy, School of Arts & Sciences

Research in my group focuses on understanding how chromatin structure affects gene regulation in eukaryotic organisms. We employ methods from statistical mechanics and polymer physics to develop biophysical models of chromatin. Another major focus area in the group is on mechanisms and theoretical descriptions of molecular evolution, especially on evolutionary constraints due to molecular energetics. Finally, we are interested in non-equlibrium dynamics and propagation on multi-dimensional landscapes and networks.
Hill Center
Room 279
848-445-1387

Vikas Nanda
Associate Professor
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School

We design proteins for applications in biomedical research, nanotechnology and use them as tools for understanding protein folding and evolution. Significant progress has been made using computer methods to engineer proteins with novel folds and functions. We maintain and develop software for protein design, structure prediction and docking of protein-ligand complexes.
Center for Advanced Biotechnology & Medicine
Room 139
848-445-9810

Joseph Naus
Professor
Statistics & Biostatistics, School of Arts & Sciences

Applied probability, sampling theory, data quality control, clustering and coincidence models, matching in DNA sequences
Hill Center
Room 571
848-445-7686

Wilma Olson
Mary I. Bunting Professor
Chemistry & Chemical Biology, School of Arts & Sciences

All of the processes necessary for the survival of a living system hinge on its ability to store and read the genetic information encoded in its DNA. The packaging of the long human genome into the very small confines of the nucleus is complicated by the necessity of maintaining the accessibility of the DNA for genetic processing. The Olson group is establishing new chemistry- and physics-based computational methodologies to unravel the mystery of how genomes can at once be tightly packed and yet available for read-out.
Wright Rieman Laboratories
Room A209B
848-445-3993

Richard Padgett
Professor
Molecular Biology & Biochemistry, School of Arts & Sciences
Principal Investigator, Waksman Institute of Microbiology

My laboratory is interested in understanding the molecular mechanisms of growth control. Our primary focus is on the transforming growth factor-β-like pathways (TGFβ) in C. elegans and Drosophila. Currently, we are examining how TGFβ receptor trafficking is regulated by genes we identified in a genetic screen.
Waksman Institute of Microbiology
Room 133
848-445-0251

Zhiping Pang
Assistant Professor
Neuroscience & Cell Biology, Robert Wood Johnson Medical School

My laboratory studies the neural basis of the regulation of feeding, satiety, metabolism and obesity. Our studies may provide insights into the neural causes and consequences of childhood obesity. We also developed novel techniques for deriving neuronal cells from primary skin cells and pluripotent stem cells, providing novel opportunities to study the pathogenesis of neurological disorders, including pediatric developmental disorders and autism spectrum disorders.
Child Health Institute of New Jersey
Room 3277
732-235-8074

Manish Parashar
Distinguished Professor
Computer Science, School of Arts & Sciences
Founding Director, Rutgers Discovery Informatics Institute
Director, The Applied Software Systems Laboratory

High-performance applied, distributed, and autonomic computing; computational and data-intensive science and engineering
Hill Center
Room 628
848-455-5388

Smita Patel
Professor
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School

The overarching goal of our research is to understand the basic mechanisms of life's essential processes including DNA replication, DNA transcription, and pathogen recognition by innate immune receptors. We specialize in quantitative characterization of protein-nucleic acids interactions and dissection of multistep enzymatic reactions into its elementary steps for complete characterization of biochemical pathways. We are pushing fluorescence based methods, transient state kinetics, single molecule kinetics, and computational kinetic modeling to characterize the mechanisms of nucleic acid motor proteins such as DNA and RNA helicases and polymerases in various processes. Our current research investigates the cooperativity and enzymatic mechanisms of multisubunit protein complexes that catalyze human mitochondrial DNA replication and transcription and self and non self RNA recognition by the RIG-I like helicase innate immune receptors. Our research has application in biotechnology and therapeutics.
Robert Wood Johnson Medical School Research Building/School of Public Health
Room 283
732-235-3371

Vladimir Pavlovic
Professor
Computer Science, School of Arts & Sciences

Sequence Analysis and Modeling Lab conducts research in computational modeling methods for analysis of multimodal and multivariate data, with particular focus on sequential data, such as time-series (video, audio, motion sensors), biomedical data (imaging, genomic, proteomic, etc.) We develop mathematical and statistical models and the accompanying algorithms that can rapidly process large and heterogeneous datasets and reveal the underlying, latent factors affecting the data.
Computational Biomedicine Imagining & Modeling Center
Room 006
848-445-8846

Ezra Peisach
Assistant Research Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Biocurator, RCSB Protein Data Bank

My research centers on the automation of biocuration activities, distributed computing and distributed infrastructure management of distributed of RCSB Protein Data Bank.
Center for Integrative Proteomics Research
Room 118
848-445-4948

John Pintar
Professor
Neuroscience & Cell Biology, Robert Wood Johnson Medical School
Graduate Program Director

The Pintar laboratory has used mammalian molecular genetic approaches to produce 16 lines of mice containing null alleles for genes involved in growth as well as nervous system development and function. Current work involves both the study of these mutant strains using multiple analytic levels as well as producing conditional knock-outs for several genes. Perhaps most notably, the lab has produced knock-outs of the entire opioid system and is now studying the consequences of these mutations on pain perception and anxiety as well as on drug-induced tolerance and dependence.
Robert Wood Johnson Medical School Research Building/School of Public Health
Room 359
732-235-4250

Vincenzo Pirrotta
Professor and Chair
Molecular Biology & Biochemistry, School of Arts & Sciences
Associate Member, Rutgers Cancer Institute of New Jersey

Chromatin structure and dynamics. polycomb silencing mechanisms, epigenetic mechanisms, developmental gene regulation, genomic programming, Drosophila genetics
Nelson Biological Laboratories
Room A121
848-445-2446

Arnold Rabson
Laura Gallagher Endowed Chair, Developmental Biology
Pediatrics; Pharmacology; & Pathology & Laboratory Medicine, Robert Wood Johnson Medical School
Director, Child Health Institute of New Jersey
Full Member, Cancer Institute of New Jersey

The Rabson laboratory studies the pathogenesis of human retroviral infections including the human T cell leukemia virus type 1-an important cause of human leukemias and inflammatory diseases, and the human immunodeficiency virus. He also studies the roles of the NF-kB transcription regulators in the genetic basis of normal and malignant T cells, and the molecular basis of hematopoiesis and childhood leukemias.
Child Health Institute of New Jersey
Room 3210
732-235-9523

Fred Roberts
Distinguished Professor
Mathematics, School of Arts & Sciences
Director Emeritus, DIMACS
Director, Homeland Security Center of Excellence CCICADA

Mathematical modeling of problems in the biological, social, and environmental sciences; biological and medical data; social science aspects of biomedicine and epidemiology; metrics and measurement; applications of discrete mathematics; information-based decision making
Center for Discrete Mathematics & Theoretical Computer Science
848-445-4303

Charles Roth
Professor
Chemical and Biochemical Engineering, School of Engineering
Biomedical Engineering, School of Engineering

The Roth laboratory applies approaches from nanobiotechnology to biomedical problems, ranging from cancer to heterotopic ossification. Our main expertise is in the development of multifunctional nanoparticles to overcome delivery barriers ranging from the systemic to intracellular, and their application for gene silencing (antisense, RNAi), drug delivery and biomedical imaging.
Chemical & Biochemical Engineering;
Biomedical Engineering
Room 205
848-445-6686

Monica Roth
Professor
Pharmacology, Robert Wood Johnson Medical School
Full Member, Rutgers Cancer Institute of New Jersey

Our research studies three stages of the retroviral life-cycle: entry, replication and integration. Retroviruses are RNA viruses capable of inducing various diseases including cancers and immunodeficiencies. The focus of our research is to study three stages in the infectious retroviral life cycle. These include the entry, replication and integration of the virus.
Robert Wood Johnson Medical Research Tower
Room 636
732-235-5048

Anirvan Sengupta
Professor
Physics & Astronomy, School of Arts & Sciences

I have two main broad subjects of interest: Condensed Matter Physics and Cellular Biology. In condensed matter physics, I have been working on effects of interaction and disorder on electrons. I am specially interested in magnetic phase transitions in metals. More technically speaking, I have tried to use insights gained from impurity models like Kondo model to understand the local physics of extended interacting systems. I have been interested in off-equilibrium dynamics of unidirectional processes, specially in context of ion pumping on cellular membranes. I am also interested in enzymatic networks and how they control gene expression or transduction.
Serin Physics
Room E263
732-445-4668

Konstantin Severinov
Professor
Molecular Biology & Biochemistry, School of Arts & Sciences
Principal Investigator, Waksman Institute of Microbiology

Transcription is the central step, and a major regulatory checkpoint of gene expression. Defective transcription regulation is the common cause of aberrant growth and development and may result in malignant transformation. Transcription is carried out by DNA-dependent RNA polymerases–large, multisubunit molecular machines. Understanding RNA polymerase (RNAP) structure and function is a key to understanding gene expression in molecular detail. The long-term objective of our research is to uncover the molecular basis of transcription mechanism and regulation through structure-functional analysis of bacterial RNAP and associated proteins. In addition, we use bacteriophage development as a model system to study temporal regulation of gene expression and to uncover novel mechanisms of transcription regulation. We also study microcins, small ribosomally-synthesized inhibitors of bacterial growth.
Waksman Institute of Microbiology
Room 224
848-445-6095

Premal Shah
Assistant Professor
Genetics, School of Arts & Sciences

Our research integrates mechanistic models of biological processes with population-genetic models to understand the forces shaping genome architecture. Our research program is focused on: evolution of codon usage bias and protein translation (by building detailed biophysical models of protein translation, we seek to explain the mechanistic bases of protein production in a cell as well as the factors that drive the evolution of biased codon usage) and epistasis in protein evolution (by combining models of protein structure and function with a population-genetic framework, we seek to explain how mutations individually and collectively influence protein evolution)
Life Sciences Building
Room 326
848-445-9664

Chenghua Shao
Assistant Research Professor
Chemistry & Chemical Biology, School of Arts & Sciences

My research focuses on data curation and analysis at the Protein Data Bank (PDB). PDB provides free public deposition and distribution services on macromolecular 3D structures determined by experimental methods. As PDB data are broadly used in biomedical research, we develop system and methods for data process and validation, to ensure data accuracy and archive consistency. With combination usage of structure biology, biochemistry, and statistics, we also perform data analysis to find trends, patterns, outliers, and the underlying biological explanation, which enables better data collection and curation to improve data quality. In addition, I supervise curation on the structural and chemical data of ligands and drugs to ensure the PDB representation of such compounds is up to the standard for their usage in biomedical research.
Center for Integrative Proteomics Research
Room 118
848-445-4968

Troy Shinbrot
Professor
Biomedical Engineering, School of Engineering

Our first area of research concerns the formation of structures during development of tissues and organs, especially in the central nervous system. This work includes the study of neuronal pathfinding following spinal cord injury and a simulation of the development of folds, for example in the mammalian cerebellum. A second area of investigation deals with the flow and mixing of both dry and wet grains. The results have applications spanning a broad range from pharmaceutic formulation to geophysical pattern formation.
Biomedical Engineering
Room 310
848-445-6584

David Shreiber
Professor & Chair
Biomedical Engineering, School of Engineering

We are interested in understanding Central Nervous System injury, repair, and regeneration. We study and attempt to dictate the tissue and cellular biomechanics associated with traumatic injury using in vivo, in situ, and computational models. We also use in vitro and computational models to investigate mechanotransduction as a mechanism underlying the response to acupuncture.
Biomedical Engineering
Room 312
848-445-6589

Eduardo Sontag
Distinguished Professor
Mathematics, School of Arts & Sciences
Graduate Program Director, Quantitative Biomedicine

Our lab studies mathematical foundations of biological systems, from the molecular level to disease models, as well as control theory and engineering applications.
Hill Center
Room 724
848-445-4552

Ruth Steward
Professor
Molecular Biology & Biochemistry, School of Arts & Sciences
Principal Investigator, Waksman Institute of Microbiology

We are studying the mechanisms controlling RNA processing (i.e. translation, localization, and stability)of specific sets of transcripts. We have identified and characterized a novel highly conserved gene, Zfrp8/PDCD2 and shown that it is essential in stem cells in flies, mouse and human and is also required for growth of cancer cells. Recently, we discovered that it is required for the nuclear export of select mRNAs and TE transcripts. It also interacts with the small ribosomal subunit and complexes with mRNA binding proteins. Our data suggest that Zfrp8/PDCD2 controls subcellular localization of select RNAs and the association of mRNA-RNP with ribosomes.
Waksman Institute of Microbiology
Room 252
848-445-3917

Ann Stock
Professor
Biochemistry & Molecular Biology, Robert Wood Johnson Medical School
Interim Director, Center for Advanced Biotechnology & Medicine

Research in the Stock laboratory focuses on investigating the molecular mechanisms of receptor-mediated signal transduction. Studies range from elucidating structure/function relationships in signaling proteins in vitro using a combination of molecular genetic, biochemical, and X-ray crystallographic methods to systems biology approaches aimed at characterizing signaling pathways in vivo. Specific interest is directed toward investigating the role and regulation of covalent modifications of proteins in bacterial signaling pathways.
Center for Advanced Biotechnology & Medicine
Room 106A
848-445-9812

Judith Storch
Distinguished Professor
Nutritional Sciences, School of Environmental & Biological Sciences
Co-Graduate Program Director

Lipids such as fatty acids and cholesterol are involved in innumerable cellular processes, including energy storage and production, membrane biogenesis, signal transduction, and the regulation of gene expression. Nevertheless, the mechanisms by which lipids are transported and targeted within cells remain largely unknown. Abnormal lipid trafficking, such as that occurring in lipid-storage diseases, can lead to severe cellular pathologies. The overall focus of research in this laboratory is on lipid traffic in cells, with particular emphasis on long-chain fatty acids, monoacylglycerols, and cholesterol.
Food Science & Nutritional Sciences Building
Room 311-D
848-932-1689

Zoltan Szekely
Research Professor
Pharmaceutics, Ernest Mario School of Pharmacy
Director, Chemical Biology Core Facility
Associate Member, Rutgers Cancer Institute of New Jersey

Antibody-drug conjugates, focusing on linkers and drugs, Tumor hypoxia and its application for prodrug design, Sequence selective DNA-targeting agents, Drug delivery by nanoparticles and bio-conjugates, Drug design, High-throughput synthesis of small molecules and peptides
William Levine Hall
Room 225
732-325-5851

Bin Tian
Professor
Microbiology, Biochemistry & Molecular Genetics, Rutgers New Jersey Medical School
Director, Center for Genome Informatics
Member, Rutgers Cancer Institute of New Jersey
Member, Human Genetics Institute of New Jersey

Our lab studies RNA biology using computational and molecular biology approaches.We are particularly interested in post-transcriptional gene regulation in development and disease. Currently, we are investigating evolution, mechanisms and consequences of alternative cleavage and polyadenylation (APA) across eukaryotic species, and its clinical relevance in human populations.
New Jersey Medical School-University Hospital Cancer Research Center
Room F1230
973-972-3615

Jay Tischfield
Duncan & Nancy MacMillan Distinguished Professor
Genetics, School of Arts & Sciences
Pediatrics & Psychiatry, Robert Wood Johnson Medical school
Founder, CEO and Scientific Director, RUCDR Infinite Biologics
Executive Director, Human Genetics Institute of New Jersey

Jay Tischfield's group is investigating the genetics and pathophysiology of complex neuropsychiatric disorders such as Tourette Syndrome and addiction disorders such as alcoholism. Other research areas include genomic structure and modifications associated with cell differentiation and maintenance of genome stability with emphasis on mechanisms of loss of heterozygosity.
Life Sciences Building
Room 136
848-445-1027

Andrew Vershon
Professor
Molecular Biology & Biochemistry, School of Arts & Sciences
Principal Investigator, Waksman Institute of Microbiology
Director, Waksman Student Scholars Program

A major focus of his research is on the regulation of transcription in the yeast, Saccharomyces cerevisiae. Specifically, he is investigating how different regulatory proteins interact to control gene expression and how these interactions influence the regulatory activity of the proteins. As Professor, Vershon is one of the most enthusiastic molecular biologists, and loves involving undergraduates in research . During the summer, Dr. Vershon works with high school teachers to encourage their students to participate in genuine molecular biology research in the Waksman Summer Scholars Institute program.
Waksman Institute of Microbiology
Room 234
848-445-2905

Michael Verzi
Assistant Professor
Genetics, School of Arts & Sciences
Member, Rutgers Cancer Institute of New Jersey
Member, Human Genetics Institute

We employ epigenomic approaches to understand how the mammalian intestine develops and functions, and to understand why this tissue is susceptible to cancer and inflammatory disease. We put particular emphasis on transcriptional regulatory mechanisms governing these processes.
Life Sciences Building
Room 127
848-445-9578

Lu Wang
Assistant Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

We develop and utilize theoretical and simulation methods to study the structure, dynamics and spectroscopy of biological systems.
Center for Integrative Proteomics Research
Room 208D
848-445-4555

Sijian Wang
Associate Professor
Statistics & Biostatistics, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

Our long-term research goal is to develop, evaluate, and disseminate effective statistical and computational methods to identify the biological mechanisms underlying complex diseases, and use the information to improve patient outcomes. We utilize advanced statistical and machine learning methods (including high-dimensional regression, causal inference, modern survival analysis, SVMs, boosting, random forest, deep learning and reinforcement learning) to addresses some of the most important statistical and computational deficiencies that are currently preventing the scientific community from turning valuable high-throughput measurements into meaningful results.
Institute for Quantitative Biomedicine
Room 308D
848-445-4562

John Westbrook
Research Professor
Chemistry & Chemical Biology, School of Arts & Sciences

My research focus centers on developing new tools and infrastructure to support technical challenges in data acquisition, data validation, data standardization, and data mining in the structural biology and life sciences domains. I have been actively involved in the development of standards for representing macromolecular structure data for the Nucleic Acid Database (NDB) and the Protein Data Bank (PDB). A continuing emphasis of my research addresses the evolution and extension of these data standards to meet both the rapidly evolving technologies within structural biology and the increased demands of the life sciences user community.
Center for Integrative Proteomics Research
Room 112
848-445-4290

Jinchuan Xing
Assistant Professor
Genetics, School of Arts & Sciences

My long-term research interest is to understand the mechanisms and consequences of human genomic variation. My current projects involve elucidating human population history and genetic adaptation at both global and regional scale, with or without disease implication.
Life Sciences Building
Room 325 & 330A
848-445-9663

Martin Yarmush
Paul & Mary Monroe Chair
Biomedical Engineering, School of Engineering

The research activities in our laboratory address various challenging areas in biotechnology and bioengineering. Among the current projects are: the development of new nanoparticle technology to enhance wound healing and siRNA delivery; microfabricated tissue-on-a-chip-systems for drug and environmental toxin testing; pulsed electric field techniques to promote scarless wound healing and wound disinfection; whole liver re-engineering through recellularization of decellularized scaffolds and revitalization perfusion of marginal organs; supercooling preservation of cells, tissues, and organs; encapsulated mesenchymal stem cells for treatment of spinal cord injury and osteoarthritis; and development of automated robotic venipuncture devices with point-of-care capabilities. Success in tackling these projects is enabled by the use of state-of-the-art techniques that include microfabrication and nanotechnology; physical biochemistry; genomics, proteomics and genetic engineering; cell biology and tissue engineering; advanced microscopic imaging; physiologic instrumentation; animal studies; and numerical simulation.
Biomedical Engineering
Room 231
848-445-6528

Darrin York
Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Resident Member, Institute for Quantitative Biomedicine

The York Group research involves the development of a broad range of theoretical methods aimed, ultimately, at providing the computational biology community with greatly improved tools for the simulation of biological macromolecules in solution. The main application focus of our group is on an extremely interesting and challenging area of biology: the study of the molecular mechanisms of RNA catalysis. This area is immensely important, not only from a fundamental biological perspective, but also for the design of medical therapies that target genetic disorders, and new biotechnology such as allosteric RNA chips.
Center for Integrative Proteomics Research
Room 308G
848-445-5199

Jasmine Young
Associate Research Professor
Chemistry & Chemical Biology, School of Arts & Sciences
Biocuration Team Lead, RCSB Protein Data Bank

I oversee practices, management, and OneDep tool developments for data deposition, curation, validation, and remediation of the Protein Databank (PDB) archive to ensure data standardization, high quality and uniformity. Collaborating with wwPDB partners globally, I represent RCSB PDB to set common annotation practices and procedures, set data standards, and establish daily operation and weekly release procedures across wwPDB sites. I also manage wwPDB projects across wwPDB partners, including development of OneDep tools, data remediation, data analysis, and strategic planning.
Center for Integrative Proteomics Research
Room 111
848-445-4920

Steve Zheng
University Professor of Pharmacology
Robert Wood Johnson Medical School
Co-Director, The Cancer Pharmacology & Pre-clinical Therapeutics Program
Resident Member, Rutgers Cancer Institute of New Jersey

Growth is the process whereby cells accumulate mass, which determines the sizes of cells, organs and organisms. Deregulation of growth is directly linked to human diseases from cancer to aging. Specifically, our current focus is on the target of rapamycin (TOR) protein, a highly conserved phosphatidylinositol kinase-related kinase (PIKK) and a central controller of cell growth. We are interested in dissecting the basic signal transduction mechanisms by TOR and in understanding the mechanisms by which cancer cells resist rapamycin and rapamycin analogs. We hope to ultimately develop more effective therapeutics against human cancer.
Rutgers Cancer Institute of New Jersey
Room 3549
732-235-6879