Intrinsically Disordered Biological Macromolecules in Cellular Signaling/Regulation



Tuesday, April 19th 2022 • 1:00 PM EST

Registration (required):


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1:00–1:05 pm
Welcome and Introductions
Stephen K. Burley, M.D., D.Phil., Rutgers Institute for Quantitative Biomedicine
Steven K. Libutti, M.D., F.A.C.S., Rutgers Cancer Institue of New Jersey
1:05–1:15 pm

Crash Course Objectives
Edmund C. Lattime, Ph.D., Rutgers Cancer Institute of New Jersey

1:15–1:45 PM

Understanding membrane-less organelles/condensates within living cells
Clifford P. Brangwynne, Ph.D., Princeton University-Chemical and Biological

Engineering, Howard Hughes Medical Institute

1:45–2:15 pm

Theory of associative polymers and implications for biomolecular condensates
Rohit V. Pappu, Ph.D., Washington University St. Louis-Biomedical Engineering

2:15–2:45 pm

How RNA encodes properties of condensates
Amy S. Gladfelter, Ph.D., University of North Carolina-Biology


2:45–3:15 pm


3:15-3:45 pm

The conformational entropy of biopolymers in the dilute phase sculpts
sequence-dependent phase boundaries
Ned S. Wingreen, Ph.D., Princeton University-Molecular Biology


3:45-4:15 pm

Building a molecular model of Ras/Raf signaling in the control of
cell proliferation
Carla Mattos, Ph.D., Northeastern University-Chemistry and Chemical Biology

4:15-4:45 pm 

How is phase behavior encoded in prion-like low-complexity domains?
Tanja Mittag, Ph.D., St. Jude Children’s Research Hospital-Structural Biology

4:45-5:00 pm

Closing remarks and acknowledgements
Stephen K. Burley, M.D., D.Phil.