QB Graduate Program Faculty Members

Alexe, Gabriela
Adjunct Faculty
Broad Institute

Computational biology
Dana-Farber Cancer Institute Dana 610
Alland, David
Professor, Chief of Infectious Diseases
Associate Dean, Clinical Research
Departmnet of Medicine

Tuberculosis pathogenesis, Tuberculosis drug resistance and persistence, Molecular diagnostics for infectious diseases, Whole genome sequencing studies of drug resistance, Molecular diagnostics for infectious diseases Whole genome sequencing studies of drug resistance
MSB Room A920C
Androulakis, Ioannis
Biomedical Engineering

Our research interests focus on the quantitative systems biology and quantitative systems pharmacology of inflammation and the interplay between immune response and biological rhythms. We are interested in delineating the intricacies of the human response to stress as well as characterizing responses to drugs, including the opportunities for personalizing oral drug formulations to target groups according to sex, age and disease status.
BME 212
Arnold, Eddy
Board of Governors Professor
Chemistry & Chemical Biology

Drug design and development targeting HIV/AIDS and flu, and structural biology of HIV-1 reverse transcriptase and integrase, flu polymerase, and bacterial RNA polymerases. A key focal area is to define the structural basis of drug resistance in infectious diseases, and to use structural information to design drugs to overcome drug resistance, including the development of generally applicable strategies.
CABM 016
Aston-Jones, Gary
Director, Brain Health Institute
Murray and Charlotte Strongwater Endowed Chair in Neuroscience and Brain Health

Brain neuromodulatory systems, cognitive performance, drug abuse, sleep and waking, and affective disorders
(732) 235-6077
Axelrod, David E.

Our lab is interested in developing quantitative prognostic factors for detecting early stages of breast and colon cancer, stratifying patients for good and poor survival, and suggesting improved treatments of patients with cancer. We combine experimental techniques such as image analysis of human biopsy specimens to measure the expression of oncogenes and tumor suppressor genes and proteins; and mathematical and computer modeling to develop agent based models of normal stem cell stochastic dynamics, abnormal proliferation and development, initiation of cancer, progression to invasive cancer, tumor heterogeneity, and chemoprevention.
Nelson B341
Baum, Jean
Distinguished Professor
Chemistry & Chemical Biology

Structural studies of proteins by nuclear magnetic resonance techniques
Proteomics 308NP
Belden, William
Associate Professor
Animal Sciences

The research in my laboratory focuses on understanding the molecular aspects of chromatin-remodeling and circadian rhythms. My lab uses the highly-tractable model eukaryote Neurospora crassa in combination with biochemical, genetic and genome-wide studies to understand the molecular mechanisms of chromatin-remodeling in clock function.
Foran Hall 326
Berman, Helen M.
Board of Governors Professor Chemistry & Chemical Biology;
Director Emerita, RCSB Protein Data Bank;
Founding Director, Center for Integrative Proteomics Research

As head of the Research Collaboratory for Structural Bioinformatics (RCSB), Director of the Protein Data Bank (PDB), and founding member of the Worldwide Protein Data Bank (wwPDB) collaboration, my group supports scientific research and education worldwide by providing the essential PDB archive of information about the experimentally-determined structures of proteins, nucleic acids, and complex assemblies. Other biological data management projects include EMDataBank, a global deposition and retrieval network for 3DEM map, model, and associated metadata, and the Structural Biology Knowledgebase, an online resource that combines the products of the NIH-funded Protein Structure Initiative research with external data annotations to provide comprehensive information about proteins.
Proteomics 208NP
Bhattacharya, Debashish
Distinguished Professor
Ecology, Evolution and Natural Resources

Work in the Bhattacharya lab primarily addresses the origin and evolution of photosynthetic eukaryotes. We use a variety of techniques ranging from algal culture and physiology, standard and single cell genomics, and functional genomics to study how algae gained and orchestrate the functions of their photosynthetic organelle, the plastid and how they adapt to changing environmental conditions. We have recently initiated a large-scale genomic and functional genomic analysis of corals and their symbionts to understand the basis of biomineralization, the genetic structure of coral populations, and their pathways of stress tolerance.
Breslauer, Kenneth J.
Dean, Biological Sciences
Vice President, Health Science Partnerships
Linus C. Pauling Professor
Chemistry & Chemical Biology

The research conducted in my laboratory combines both biophysical and bioorganic chemistry to investigate the following four interrelated programs of research.
Bromberg, Yana
Assistant Professor
Biochemistry and Microbiology

Bioinformatics approaches to protein function prediction and genome variation analysis. Our main goal is to develop fast, accurate, and meaningful ways of analyzing this growing deluge of biological data and to bring these developments bench- (or patient-) side. To make our predictions we rely on a number of sequence-based features (including evolutionary information and other predictor results) and utilize a variety of methodologies (including Neural Nets, SVMs and random forests).
(848) 932-5638
Brzustowicz, Linda
Distinguished Professor and Chair, Department of Genetics
Full Academic Member, Human Genetics Institute of New Jersey

My research group applies the techniques of molecular and statistical genetics to approach clinically relevant problems in neuroscience, with the ultimate goal of understanding gene function in both the pathologic and normal states. We are currently studying schizophrenia, autism, and specific language impairment (SLI). Work directly conducted by my group includes development of phenotype definitions, subject recruitment and assessment (for autism and SLI), genotyping and statistical analysis for linkage and association studies, comparative genomic analysis, and gene expression studies.
(848) 445-3331
Burley, Stephen K.
Director, Center for Integrative Proteomics Research
Director, RCSB Protein Data Bank
Founding Director, Institute for Quantitative Biomedicine at Rutgers
Distinguished Professor, Chemistry & Chemical Biology
Member, Rutgers Cancer Institute of New Jersey
Member, Rutgers University Academic Senate

As the Director of the Center for Integrative Proteomics Research, a Professor in the Department of Chemistry and Chemical Biology at Rutgers, The State University of New Jersey, and a Member of The Cancer Institute of New Jersey, I aim to foster interactive networks of research groups that utilize multidisciplinary approaches to address important biological and biomedical challenges.
Proteomics 117
Case, David
Distinguished Professor
Chemistry & Chemical Biology

Our group studies theoretical chemistry of biomolecules, using molecular dynamics simulations of proteins and nucleic acids, electronic structure calculations of transition-metal complexes that model active sites in metalloenzymes, and development and application of methods for NMR structure determination.
Proteomics 208AB
Chan, Chang S
Assistant Professor
Rutgers Cancer Institute of New Jersey

High-throughput sequencing and integration of data in the study of genetics of cancer, complex diseases, and gene regulation, and Integration of diverse data with phenotypes for a systems level understanding of biology
(732) 235-7363
Chaudhary, Sunita
Director, Research Education
Adjunct Assistant Professor of Surgery
Surgical Oncology
Rutgers Cancer Institute of New Jersey

Evaluating interventions that promote research career choice by minority youth.
Chauhan, Neeraj
Assistant Professor
Public Health Research Institute
Department of Microbiology & Molecular Genetics

The focus of my current research is the opportunistic human pathogenic yeast, Candida albicans. It is the leading cause of invasive fungal disease in premature infants, surgical patients and cancer patients receiving immunosuppressive chemotherapy. My research is directed to elucidate the complex signaling pathways that contribute to the virulence & pathogenesis of this organism. Our approaches include molecular, biochemical and immunological techniques to study these events. This involves isolation of encoding genes, construction of knock-out strains to study gene function, DNA Microarrays, and GFP localization etc. Two component signaling proteins (histidine kinases and response regulators) and downstream MAP kinases are the main focus of research.
Chundawat, Shishir
Assistant Professor
Chemical and Biochemical Engineering

Our group takes a 'glycan-centric' approach to address a variety of problems in bioenergy, biomedical, and biomaterials engineering.
School of Engineering C150A
Comoletti, Davide
Assistant Professor
Department of Neuroscience and Cell Biology

Structural and molecular basis of synapse formation and connectivity in relation to autism spectrum disorders
Craelius, William
Biomedical Engineering

Bioinformatics, specializing in developing predictive models for outcome following traumatic brain injury
Dai, Wei
Assistant Professor
Associate II Member, Cancer Metabolism and Growth Program, RCINJ
Department of Cell Biology & Neuroscience

Our research focuses on charactering the structures of macromolecular machinery in their cellular context using three-dimensional (3D) cryo-electron tomography (cryoET) and correlative light and electron microscopy.
Proteomics 208G
(848) 445-6560
Drake, Justin
Assistant Professor
Department of Medicine, Robert Wood Johnson Medical School
Resident Member, Rutgers Cancer Institute of New Jersey

Research in the Drake Lab focuses on blending basic and translational research approaches to better understand the signaling networks in lethal metastatic castration resistant prostate cancer, and how to more effectively treat patients who are suffering from this disease using rationalized targeted therapies.
(732) 235-7017
Driscoll, Monica
Molecular Biology & Biochemistry

Developmental neurogenetics. molecular genetics of neuronal cell death. mechanosensory transduction in touch and feeling. molecular mechanisms of aging.
Nelson A232
Duffy, Siobain
Associate Professor
Ecology, Evolution and Natural Resources

The Duffy lab uses a blend of computational and experimental approaches to understand and model the evolution of emerging RNA and single-stranded DNA viruses.
Ebright, Richard H.
Board of Governors Professor of Chemistry and Chemical Biology
Chemistry & Chemical Biology

Richard H. Ebright seeks to understand structures, mechanisms, and regulation of bacterial transcription complexes and to identify, characterize, and develop small-molecule inhibitors of bacterial transcription for application as antituberculosis agents and broad-spectrum antibacterial agents.
Waksman Institute 201A
Falkowski, Paul
Distinguished Professor, Bennett L. Smith Chair in Business and Natural Resources
Departments of Earth and Planetary Sciences and Marine and Coastal Sciences
Board of Governors Professor and Director of the Rutgers Energy Institute
Geological Sciences & Marine & Coastal Sciences

Biogeochemical cycles, photosynthesis, biological oceanography, molecular biology, biochemistry and biophysics, physiological adaptation, plant physiology, evolution, mathematical modeling, symbiosis
Foran, David J.
Professor / Dir. Biomedical Informatics & Computational
Department of Pathology, Lab Medicine & Radiology

A major concentration for my laboratory has been the development of a family of data-mining, imaging and computational tools for characterizing a wide range of malignancies and elucidating the role that protein and molecular expression plays in disease onset and progression. My training, experience and expertise gained while leading and supporting multi-investigator projects in computational imaging, computer-assisted diagnostics, bioinformatics, team-based software development and high-performance computing have provided me with the requisite tools and skills to work in partnership with basic, clinical and translational researchers to address fundamental problems in cancer detection, patient stratification, disease management, and outcomes studies.
RCINJ 3552
Freundlich, Joel
Associate Professor
Departmnet of Pharmacology, Physiology, and Neuroscience

The Freundlich group is a chemical biology lab that utilizes a multi-disciplinary approach to study infectious diseases, with a specific focus on tuberculosis. Within the Department of Pharmacology & Physiology and the Department of Medicine (Division of Infectious Diseases, Center for Emerging & Re-emerging Pathogens), we focus on 1) the development and application of novel computational methods to discover and optimize chemical probes with which to study the pathogenesis of disease and 2) the utilization of biological techniques to elucidate how each probe affects disease pathogenesis, often through the complex modulation of more than one biological target. We assert that this approach has significant potential to seed the discovery of novel biological targets and small molecule drug discovery hits/leads.
Gajic, Zoran
Graduate Program Director
Electrical and Computer Engineering

Research interests are in controls systems, energy systems (fuel and solar cells, wind, smart grids), wireless communications, and networking.
(732) 445-3415
Ganesan, Shridar
Co-Chair, Research Working Group in Cancer Genomics and Proteomics
Associate Professor, Robert Wood Johnson Medical School

DNA repair mechanisms and chromatin biology; Biology of BRCA1 and 53BP1 in DNA repair, tumorigenesis, and chemosensitivity; Genomic classification of human cancer
Gartenberg, Marc R.
Biochemistry & Molecular Biology

My lab investigates the ways that heterochromatin is assembled, maintained and inherited. Our recent work includes focus on the specialized roles of heterochromatin in sister chromatid cohesion. We use budding yeast as a model eukaryotic system where we have developed molecular biological tools to ask questions at the mechanistic level.
School of Public Health 276
Gatza, Michael
Assistant Professor
Department of Radiation Oncology, Robert Wood Johnson Medical School
Resident Member, Rutgers Cancer Institute of New Jersey

Our research program is focused on understanding the mechanisms of oncogenic signaling and therapeutic response in human breast and ovarian cancers. Leveraging a multi-disciplinary approach spanning cancer biology, molecular biology, genomics, genetics, bioinformatics, and statistics allows us to identify relevant genomic alterations in human tumors and then experimentally investigate the mechanisms by which these alterations affect given tumor phenotypes in order to develop rational therapeutic strategies based on the unique complement of genomic alterations present in each patient's tumor.
Georgopoulos, Panos
Professor of Environmental and Occupational Health
Environmental and Occupational Health, SPH
Rutgers Biomedical and Health Sciences & EOHSI

Multiscale computational modeling of environmental and biological systems and of their interactions; computational toxicology; quantitative frameworks for adverse outcome pathways in environmental health systems.
Enviroinformatics, bioinformatics, and socioinformatics for public health applications; predictive data analytics for human exposures and associated health outcomes.
Ghesani, Nasrin
Associate Professor
Radiology, NJMS

Molecular imaging and Positron Emission Tomography
Inouye, Masayori
Distinguished Professor
Biochemistry & Molecular Biology

Molecular biology of cellular adaptation to stresses
CABM 140
Irvine, Kenneth
Molecular Biology & Biochemistry

We are engaged in projects whose long-term goal is to define relationships between patterning and growth in developing and regenerating organs.
Waksman 246
Javanmard, Mehdi
Assistant Professor
Electrical and Computer Engineering

Nanobiotechnology; BioMEMS; Point of care diagnostics; Protein Biomarker detection; Microfluidics; Electrokinetics; Applications of nanotechnology to medicine and biology; Wearable Devices for Health Monitoring.
(848) 445-3382
Jha, Shantenu
Associate Professor
Electrical and Computer Engineering

High-performance and distributed computing; computational and data-intensive science and engineering
Kern, Andrew
Assistant Professor

Population and Comparative Genomics; Computational Biology; Machine Learning
Nelson C217
Khare, Sagar
Assistant Professor
Chemistry & Chemical Biology

The Khare laboratory is interested in understanding the design principles of biological functional evolution using a combination of computational protein design and experimental characterization methods to design novel, non-natural protein function. Our design goals include therapeutic enzymes, and novel biosynthetic and biodegradative pathways.
Proteomics 208M/204
Khiabanian, Hossein
Assistant Professor
Pathology in the Division of Medical Informatics, Rutgers Cancer Institute of New Jersey

The research of our laboratory at Rutgers Cancer Institute of New Jersey focuses on cancer genomics and computational biology. We develop novel analytical methods to understand the underlying genetics of human diseases and the molecular epidemiology of disease-causing organisms using high-throughput genomic data. We are interested in identifying prognostic markers in cancer, as well as studying tumor clonal evolution, especially in the contexts of therapeutic resistance, disease transformation, and relapse.
Kimball, David
Associate VP, Translational Sciences
Research Professor, Dept of Medicinal Chemistry

Medicinal chemistry, drug discovery and development across therapeutic areas: oncology, Alzheimer's, neuropathic pain, cardiovascular disease. Responsible for Rutgers Translational Sciences group, which enables biomedical research across Rutgers University.
Kolassa, John
Statistics and Biostatistics

Explore approximate and exact statistical methods for small data sets.
(848) 445-7674
Lattime, Edmund

Immunotherapy of solid tumors, Gene therapy of solid tumors, Tumor immunology, Cancer vaccines
Lawson, Catherine
Associate Research Professor
Department of Chemistry & Chemical Biology

My research explores the diverse landscape of biological structure-function relationships, with the goal of improving our fundamental understanding of life processes. My current projects involve structure database development (EMDataBank, Protein Data Bank), with particular emphasis on improving representation of large biological assemblies.
Proteomics 109
Lebowitz, Joel
Director, Center for Mathematical Sciences Research
George William Hill Professor of Mathematics
Department of Mathematics

Mathematical physics and statistical mechanics
Hill 612
Lee, Jeehiun Katherine
Chemistry & Chemical Biology

Our group focuses on computational and experimental studies of damaged DNA and related enzymes.
Wright Rieman 382/372
Lee, Kibum
Department of Chemistry & Chemical Biology

The primary research interest of my group is to develop and integrate nanotechnologies and chemical functional genomics to modulate signaling pathways in stem cells towards specific cell lineages or behaviors. In particular, we are exploring critical problems in cancer research and stem cell biology pertaining to the cell-microenvironmental interactions, and how to control these interactions at the subcellular and single cell level using chemical biology and nanotechnology. From this research effort, we have developed innovative technology platforms that may overcome the critical barriers to harnessing the full therapeutic potential of stem cells for regenerative medicine and personized medicine.
Wright Rieman 315
Lee, Sang-Hyuk
Assistant Professor
Physics & Astronomy

Lee lab is a single-molecule biophysics/biophotonics laboratory. Our lab features a wetlab, cell culture facility, and a one-of-a-kind single-molecule optical instrument. Utilizing advanced fluorescent microscopy, optical tweezers, and digital holography, we are pushing the limit of our understanding of biological processes at the single-molecule level.
Proteomics 308A
Lobel, Peter
Biochemistry & Molecular Biology

Hereditary neurodegenerative diseases, functional genomics, lysosomes, protein targeting
CABM 204/214, 216
Ludescher, Richard
Dean of Academic Programs
Professor, Dept of Food Science
School of Environmental and Biological Sciences, Rutgers University

The research in my lab is concerned with the physical chemistry of edible molecules and biomaterials, with the physical properties, molecular mobility, and molecular states of amorphous solids, and with developing novel applications of luminescence spectroscopy, and especially the identification, characterization and use of edible optical luminescent (fluorescent and phosphorescent) probes, to solve basic scientific as well as practical problems related to the structure, dynamics and function of edible biomaterials.
Lukac, David M.
Associate Professor, Microbiology, Biochemistry, and Molecular Genetics
Director, Graduate Track in Infection, Immunity, and Inflammation

We have two major projects: 1. using herpesvirus infection models to investigate the specificity of cellular responses to the Notch signal transduction pathway, and application of learned paradigms to non-viral cancers. 2. investigating the intracellular dynamics of histone deacetylase 6 in autophagy, the stress response, and herpesviral infection.
Marcotrigiano, Joseph
Associate Professor
Chemistry & Chemical Biology

The Marcotrigiano Laboratory studies the basic mechanism of HIV, hepatitis C virus and alphavirus replication, as well as the innate, cellular response to viral infection.
CABM 237
Mathews, Michael B.
Professor & Chair, Department of Biochemistry & Molecular Biology

Regulatory RNAs; RNA-protein interactions; Novel targets for anti-HIV drugs
Messing, Joachim
Director, Waksman Institute of Microbiology
Selman A. Waksman Chair in Molecular Genetics
University Professor of Molecular Biology ,Waksman Institute

We use comparative genomics to study the diversification and expression of copies of gene families through positional information.
Metaxas, Dimitris
Distinguished Professor
Computer Science

Physics-based techniques for modeling of organ shape and motion; computer graphics and animation; computational vision; medical imaging
Hill 11
Millonig, James
Associate Professor
Neuroscience & Cell Biology

My lab studies dorsal CNS development by taking the unique approach of combining mouse genetics with neuroanatomy. Our goal is to identify the pathways, which control the generation and differentiation of dorsal CNS neurons.
(848)Neuroscience & Cell Biolo
Mischaikow, Konstantin
Distinguished Professor

We use algebraic and computational topological methods to investigate the global structures of multiparameter nonlinear dynamical systems and to study high dimensional spatially-temporally complex data sets.
Hill 265
Mitrofanova, Antonina
Assistant Professor and Director of Biomedical Informatics Research
Department of Health Informatics, School of Health Professions

Her laboratory investigates transcriptional as well as epigenetic mechanisms that drive cancer initiation, progression, and metastases. Furthermore, her lab interests expand to elucidating mechanisms of drug response and resistance and identifying novel drug and drug combinations to target cancer malignancies.
Moghe, Prabhas
Distinguished Professor
Biomedical Engineering

The Moghe laboratory has four broad research areas. Two of the areas focus on the design, synthesis, characterization, and mechanisms of interactions of nanoscale materials with cellular matrix proteins. A third area is focused on cell reporter-based biological profiling biological profiling of synthetic polymeric biomaterials for regenerative medicine using high content imaging and high throughput evaluation methods. The fourth effort is on studies of human embryonic stem cell pluripotency and differentiation behaviors on biomaterials.
BME 315
Montelione, Gaetano
Distinguished Professor
Molecular Biology & Biochemistry

We are interested in understanding basic principles of protein evolution and function. In a wide range of collaborations, we utilize structural bioinformatics and experimental methods, including NMR spectroscopy, X-ray crystallography, protein structure prediction, and small angle X-ray scattering (SAXS), to study proteins and protein complexes selected from interaction networks associated with cancer biology and the innate immune response.
CABM 307
Morozov, Alexandre
Associate Professor
Physics & Astronomy

Research in my group focuses on understanding how chromatin structure affects gene regulation in eukaryotic organisms. We employ methods from statistical mechanics and polymer physics to develop biophysical models of chromatin. Another major focus area in the group is on mechanisms and theoretical descriptions of molecular evolution, especially on evolutionary constraints due to molecular energetics. Finally, we are interested in non-equlibrium dynamics and propagation on multi-dimensional landscapes and networks.
Hill 279
Nanda, Vikas
Associate Professor
Biochemistry & Molecular Biology

We design proteins for applications in biomedical research, nanotechnology and use them as tools for understanding protein folding and evolution. Significant progress has been made using computer methods to engineer proteins with novel folds and functions. We maintain and develop software for protein design, structure prediction and docking of protein-ligand complexes.
Naus, Joseph
Statistics and Biostatistics. SAS

Applied probability, sampling theory, data quality control, clustering and coincidence models, matching in DNA sequences
Hill Center 571
Olson, Wilma
Mary I. Bunting Professor
Chemistry & Chemical Biology

All of the processes necessary for the survival of a living system hinge on its ability to store and read the genetic information encoded in its DNA. The packaging of the long human genome into the very small confines of the nucleus is complicated by the necessity of maintaining the accessibility of the DNA for genetic processing. The Olson group is establishing new chemistry- and physics-based computational methodologies to unravel the mystery of how genomes can at once be tightly packed and yet available for read-out.
Wright A209B
Padgett, Richard
Professor, Molecular Biology and Biochemistry, Waksman Institute Co-director, Molecular Biosciences Graduate Program
Molecular Biology & Biochemistry

My laboratory is interested in understanding the molecular mechanisms of growth control. Our primary focus is on the transforming growth factor-β-like pathways (TGFβ) in C. elegans and Drosophila. Currently, we are examining how TGFβ receptor trafficking is regulated by genes we identified in a genetic screen.
Waksman 133
Parashar, Manish
Founder & Director Rutgers Discovery Informatics Institute (RDI2)
Distinguished Professor, Computer Science
Director, Associate Director, Rutgers Center for Information Assurance
Director, The Applied Software Systems Laboratory (TASSL)
Full Member of RCINJ

High-performance applied, distributed, and autonomic computing; computational and data-intensive science and engineering
Patel, Smita
Biochemistry & Molecular Biology

Mechanisms of mitochondrial DNA replication and transcription; innate immunity receptors in virus recognition
Public Health Building 283
Pavlovic, Vladimir
Associate Professor
Computer Science

Applied machine learning and probabilistic inference; bioinformatics
Hill 312
848-445-2001 x2654
Pintar, John
Department of Neuroscience & Cell Biology

Genetic and microarray analysis of endogenous opioid systems; insulin-like growth factor systems in development and cancer; post-translational processing enzymes
Rabson, Arnold
Director, Child Health Institute of NJ; Professor; Associate Dea
Genetics, Microbiology & Immunology; Pathology & Laboratory Medicine

Gene regulation in cancer, human retroviral infections
Child Health Institute of NJ 3210
Roberts, Fred
Director of CCICADA Director Emeritus and Senior Advisor, DIMACS

Mathematical modeling of problems in the biological, social, and environmental sciences; biological and medical data; social science aspects of biomedicine and epidemiology; metrics and measurement; applications of discrete mathematics; information-based decision making
Roth, Charles
Biomedical Engineering

The Roth laboratory applies approaches from nanobiotechnology to biomedical problems, ranging from cancer to heterotopic ossification. Our main expertise is in the development of multifunctional nanoparticles to overcome delivery barriers ranging from the systemic to intracellular, and their application for gene silencing (antisense, RNAi), drug delivery and biomedical imaging.
BME 205
848-445-4500 x6205
Roth, Monica
Full Member, Genome Instability and Cancer Genetics Program
Pharmacology and Biochemistry and Molecular Biology

Retroviruses integration, reverse transcriptase, envelope proteins, gene therapy, targeted entry, structural studies, tethering to mitotic chromosomes
Tower 636
Sengupta, Anirvan
Physics & Astronomy

Informational processing systems in cell biology; signal transduction networks and transcriptional circuits; statistical physics; signal processing and network analysis
Hill 275
Severinov, Konstantin
Molecular Biology & Biochemistry

Genetic and biochemical analysis of RNA polymerases from E. coli and yeast, site-directed modification of proteins
Waksman 224
Shah, Premal
Assistant Professor
Department of Genetics

Our research integrates mechanistic models of biological processes with population-genetic models to understand the forces shaping genome architecture. Our research program is focused on: evolution of codon usage bias and protein translation (by building detailed biophysical models of protein translation, we seek to explain the mechanistic bases of protein production in a cell as well as the factors that drive the evolution of biased codon usage) and epistasis in protein evolution (by combining models of protein structure and function with a population-genetic framework, we seek to explain how mutations individually and collectively influence protein evolution)
Shinbrot, Troy
Biomedical Engineering

Our first area of research concerns the formation of structures during development of tissues and organs, especially in the central nervous system. This work includes the study of neuronal pathfinding following spinal cord injury and a simulation of the development of folds, for example in the mammalian cerebellum. A second area of investigation deals with the flow and mixing of both dry and wet grains. The results have applications spanning a broad range from pharmaceutic formulation to geophysical pattern formation.
BME C119
Shreiber, David
Biomedical Engineering

We are interested in understanding Central Nervous System injury, repair, and regeneration. We study and attempt to dictate the tissue and cellular biomechanics associated with traumatic injury using in vivo, in situ, and computational models. We also use in vitro and computational models to investigate mechanotransduction as a mechanism underlying the response to acupuncture.
Biomedical Engineering 312
Sontag, Eduardo
Graduate Program Director, Quantitative Biomedicine
Distinguished Professor, Mathematics

Our lab studies mathematical foundations of biological systems, from the molecular level to disease models, as well as control theory and engineering applications.
Hill 724
Steward, Ruth
Molecular Biology & Biochemistry

Nuclear migration; RNA localization and patterning in Drosophila
Waksman 252
Stock, Ann
Professor and Interim Director, Center for Advanced Biotechnology and Medicine
Biochemistry & Molecular Biology

Research in the Stock laboratory focuses on investigating the molecular mechanisms of receptor-mediated signal transduction. Studies range from elucidating structure/function relationships in signaling proteins in vitro using a combination of molecular genetic, biochemical, and X-ray crystallographic methods to systems biology approaches aimed at characterizing signaling pathways in vivo. Specific interest is directed toward investigating the role and regulation of covalent modifications of proteins in bacterial signaling pathways.
Storch, Judith
Distinguished Professor
Nutritional Sciences

Cellular lipid transport, structure and function of lipid transport proteins, intestinal lipid transport, and systemic energy metabolism
Szekely, Zoltan

Antibody-drug conjugates, focusing on linkers and drugs, Tumor hypoxia and its application for prodrug design, Sequence selective DNA-targeting agents, Drug delivery by nanoparticles and bio-conjugates, Drug design, High-throughput synthesis of small molecules and peptides
Thomas, Dennis
Associate Research Professor
Center for Integrative Proteomics Research

848 445-5302
Tian, Bin
Microbiology, Biochemistry and Molecular Genetics/NJMS

Our lab studies RNA biology using computational and molecular biology approaches.We are particularly interested in post-transcriptional gene regulation in development and disease. Currently, we are investigating evolution, mechanisms and consequences of alternative cleavage and polyadenylation (APA) across eukaryotic species, and its clinical relevance in human populations.
Cancer Center Room F1230
Tischfield, Jay
Distinguished Professor

Jay Tischfield's group is investigating the genetics and pathophysiology of complex neuropsychiatric disorders such as Tourette Syndrome and addiction disorders such as alcoholism. Other research areas include genomic structure and modifications associated with cell differentiation and maintenance of genome stability with emphasis on mechanisms of loss of heterozygosity.
Life Sciences 136
Vershon, Andrew
Molecular Biology & Biochemistry

Transcriptional regulation in yeast
Waksman 234
Verzi, Michael
Assistant Professor
Full Member of Genome Instability and Cancer Genetics Program

We employ epigenomic approaches to understand how the mammalian intestine develops and functions, and to understand why this tissue is susceptible to cancer and inflammatory disease. We put particular emphasis on transcriptional regulatory mechanisms governing these processes.
Wang, Lu
Assistant Professor
Chemistry & Chemical Biology

We develop and utilize theoretical and simulation methods to study the structure, dynamics and spectroscopy of biological systems.
Center for Integrative Proteomics Research 208D
Westbrook, John
Research Professor
Department of Chemistry & Chemical Biology

My research focus centers on developing new tools and infrastructure to support technical challenges in data acquisition, data validation, data standardization, and data mining in the structural biology and life sciences domains. I have been actively involved in the development of standards for representing macromolecular structure data for the Nucleic Acid Database (NDB) and the Protein Data Bank (PDB). A continuing emphasis of my research addresses the evolution and extension of these data standards to meet both the rapidly evolving technologies within structural biology and the increased demands of the life sciences user community.
Proteomics 112
Xing, Jinchuan
Assistant Professor
Department of Genetics

Genomic Variation Mobile Elements Disease Gene Identification
Yarmush, Martin
Paul and Mary Monroe Chair and Distinguished Professor
Biomedical Engineering

The research activities in our laboratory address various challenging areas in biotechnology and bioengineering. Among the current projects are: the development of new nanoparticle technology to enhance wound healing and siRNA delivery; microfabricated tissue-on-a-chip-systems for drug and environmental toxin testing; pulsed electric field techniques to promote scarless wound healing and wound disinfection; whole liver re-engineering through recellularization of decellularized scaffolds and revitalization perfusion of marginal organs; supercooling preservation of cells, tissues, and organs; encapsulated mesenchymal stem cells for treatment of spinal cord injury and osteoarthritis; and development of automated robotic venipuncture devices with point-of-care capabilities. Success in tackling these projects is enabled by the use of state-of-the-art techniques that include microfabrication and nanotechnology; physical biochemistry; genomics, proteomics and genetic engineering; cell biology and tissue engineering; advanced microscopic imaging; physiologic instrumentation; animal studies; and numerical simulation.
BME 231
York, Darrin
Chemistry & Chemical Biology

The York Group research involves the development of a broad range of theoretical methods aimed, ultimately, at providing the computational biology community with greatly improved tools for the simulation of biological macromolecules in solution. The main application focus of our group is on an extremely interesting and challenging area of biology: the study of the molecular mechanisms of RNA catalysis. This area is immensely important, not only from a fundamental biological perspective, but also for the design of medical therapies that target genetic disorders, and new biotechnology such as allosteric RNA chips.
Proteomics 308G
Zheng, Steve
Co-Director, The Cancer Pharmacology and Pre-clinical Therapeutics Program
Rutgers Cancer Institute of New Jersey

(732) 235-6879